| 1. | Barry Bonds - 73 - 2001 - San Francisco Giants NL 1 |
| 2. | Mark McGwire - 70 - 1998 - St. Louis Cardinals NL 2 |
| 3. | Sammy Sosa - 66 - 1998 - Chicago Cubs NL 3 |
| 4. | Mark McGwire - 65 - 1999 - St. Louis Cardinals NL 4 |
| 5. | Sammy Sosa - 64 - 2001 - Chicago Cubs NL 5 |
| 6. | Sammy Sosa - 63 - 1999 - Chicago Cubs NL 6 |
| 7. | Roger Maris - 61 - 1961 - New York Yankees AL 7 |
| 8. | Babe Ruth - 60 - 1927 - New York Yankees AL 8 |
| 9. | Babe Ruth - 59 - 1921 - New York Yankees AL 9 |
| 10. | Jimmie Foxx - 58 - 1932 - Philadelphia Athletics AL 10 |
| 11. | Hank Greenberg - 58 - 1938 - Detroit Tigers AL |
| 12. | Ryan Howard - 58 - 2006 - Philadelphia Phillies NL |
| 13. | Mark McGwire - 58 - 1997 - Oakland Athletics AL, St. Louis Cardinals NL |
| 14. | Luis Gonzalez - 57 - 2001 - Arizona Diamondbacks NL 14 |
| 15. | Alex Rodriguez - 57 - 2002 - Texas Rangers AL |
| 16. | Ken Griffey, Jr. - 56 - 1998 - Seattle Mariners AL 16 |
| 17. | Ken Griffey, Jr. - 56 - 1997 - Seattle Mariners AL |
| 18. | Hack Wilson - 56 - 1930 - Chicago Cubs NL |
| 19. | Ralph Kiner - 54 - 1949 - Pittsburgh Pirates NL 19 |
| 20. | Mickey Mantle - 54 - 1961 - New York Yankees AL |
| 21. | David Ortiz - 54 - 2006 - Boston Red Sox AL |
| 22. | Alex Rodriguez - 54 - 2007 - New York Yankees AL |
| 23. | Babe Ruth - 54 - 1928 - New York Yankees AL |
| 24. | Babe Ruth - 54 - 1920 - New York Yankees AL |
| 25. | George Foster - 52 - 1977 - Cincinnati Reds NL 25 |
| 26. | Mickey Mantle - 52 - 1956 - New York Yankees AL |
| 27. | Willie Mays - 52 - 1965 - San Francisco Giants NL |
| 28. | Mark McGwire - 52 - 1996 - Oakland Athletics AL |
| 29. | Alex Rodriguez - 52 - 2001 - Texas Rangers AL |
| 30. | Jim Thome - 52 - 2002 - Cleveland Indians AL |
| 31. | Cecil Fielder - 51 - 1990 - Detroit Tigers AL 31 |
| 32. | Andruw Jones - 51 - 2005 - Atlanta Braves NL |
| 33. | Ralph Kiner - 51 - 1947 - Pittsburgh Pirates NL |
| 34. | Willie Mays - 51 - 1955 - New York Giants NL |
| 35. | Johnny Mize - 51 - 1947 - New York Giants NL |
| 36. | Brady Anderson - 50 - 1996 - Baltimore Orioles AL 36 |
| 37. | Albert Belle - 50 - 1995 - Cleveland Indians AL |
| 38. | Prince Fielder - 50 - 2007 - Milwaukee Brewers NL |
| 39. | Jimmie Foxx - 50 - 1938 - Boston Red Sox AL |
| 40. | Sammy Sosa - 50 - 2000 - Chicago Cubs NL |
| 41. | Greg Vaughn - 50 - 1998 - San Diego Padres NL |
| 42. | Albert Belle - 49 - 1998 - Chicago White Sox AL 42 |
| 43. | Barry Bonds - 49 - 2000 - San Francisco Giants NL |
| 44. | Andre Dawson - 49 - 1987 - Chicago Cubs NL |
| 45. | Lou Gehrig - 49 - 1936 - New York Yankees AL |
| 46. | Lou Gehrig - 49 - 1934 - New York Yankees AL |
| 47. | Shawn Green - 49 - 2001 - Los Angeles Dodgers NL |
| 48. | Ken Griffey, Jr. - 49 - 1996 Seattle Mariners AL |
| 49. | Todd Helton - 49 - 2001 - Colorado Rockies NL |
| 50. | Harmon Killebrew - 49 1969 Minnesota Twins AL |
| 51. | Harmon Killebrew - 49 1964 Minnesota Twins AL |
| 52. | Ted Kluszewski - 49 - 1954 - Cincinnati Redlegs NL |
| 53. | Willie Mays - 49 - 1962 - San Francisco Giants NL |
| 54. | Mark McGwire - 49 - 1987 - Oakland Athletics AL |
| 55. | Albert Pujols - 49 - 2006 - St. Louis Cardinals NL |
| 56. | Frank Robinson - 49 - 1966 - Baltimore Orioles AL |
| 57. | Babe Ruth - 49 - 1930 - New York Yankees AL |
| 58. | Sammy Sosa - 49 - 2002 - Chicago Cubs NL |
| 59. | Jim Thome - 49 - 2001 - Cleveland Indians AL |
| 60. | Larry Walker - 49 - 1997 - Colorado Rockies NL |
| 61. | Albert Belle - 48 - 1996 - Cleveland Indians AL 61 |
| 62. | Adrian Beltre - 48 - 2004 - Los Angeles Dodgers NL |
| 63. | Jimmie Foxx - 48 - 1933 - Philadelphia Athletics AL |
| 64. | Ken Griffey, Jr. - 48 - 1999 - Seattle Mariners AL |
| 65. | Frank Howard - 48 - 1969 - Washington Senators AL |
| 66. | Harmon Killebrew - 48 - 1962 - Minnesota Twins AL |
| 67. | Dave Kingman - 48 - 1979 - Chicago Cubs NL |
| 68. | Alex Rodriguez - 48 - 2005 - New York Yankees AL |
| 69. | Mike Schmidt - 48 - 1980 - Philadelphia Phillies NL |
| 70. | Willie Stargell - 48 - 1971 - Pittsburgh Pirates NL |
| 71. | Hank Aaron - 47 - 1971 - Atlanta Braves NL 71 |
| 72. | Jeff Bagwell - 47 - 2000 - Houston Astros NL |
| 73. | Ernie Banks - 47 - 1958 - Chicago Cubs NL |
| 74. | George Bell - 47 - 1987 - Toronto Blue Jays AL |
| 75. | Andres Galarraga - 47 - 1996 - Colorado Rockies NL |
| 76. | Lou Gehrig - 47 - 1927 - New York Yankees AL |
| 77. | Troy Glaus - 47 - 2000 - Anaheim Angels AL |
| 78. | Juan Gonzalez - 47 - 1996 - Texas Rangers AL |
| 79. | Ryan Howard - 47 - 2007 - Philadelphia Phillies NL |
| 80. | Reggie Jackson - 47 - 1969 - Oakland Athletics AL |
| 81. | Ralph Kiner - 47 - 1950 - Pittsburgh Pirates NL |
| 82. | Ted Kluszewski - 47 - 1955 - Cincinnati Redlegs NL |
| 83. | Eddie Mathews - 47 - 1953 - Milwaukee Braves NL |
| 84. | Willie Mays - 47 - 1964 - San Francisco Giants NL |
| 85. | Kevin Mitchell - 47 - 1989 - San Francisco Giants NL |
| 86. | David Ortiz - 47 - 2005 - Boston Red Sox AL |
| 87. | Rafael Palmeiro - 47 - 2001 - Texas Rangers AL |
| 88. | Rafael Palmeiro - 47 - 1999 - Texas Rangers AL |
| 89. | Alex Rodriguez - 47 - 2003 - Texas Rangers AL |
| 90. | Babe Ruth - 47 - 1926 - New York Yankees AL |
| 91. | Jim Thome - 47 - 2003 - Philadelphia Phillies NL |
| 92. | Barry Bonds - 46 - 2002 - San Francisco Giants NL 92 |
| 93. | Barry Bonds - 46 - 1993 - San Francisco Giants NL |
| 94. | Jose Canseco - 46 - 1998 - Toronto Blue Jays AL |
| 95. | Vinny Castilla - 46 - 1998 - Colorado Rockies NL |
| 96. | Orlando Cepeda - 46 - 1961 - San Francisco Giants NL |
| 97. | Joe DiMaggio - 46 - 1937 - New York Yankees AL |
| 98. | Adam Dunn - 46 - 2004 - Cincinnati Reds NL |
| 99. | Lou Gehrig - 46 - 1931 - New York Yankees AL |
| 100. | Jim Gentile - 46 - 1961 - Baltimore Orioles AL 100 |
| 101. | Juan Gonzalez - 46 - 1993 - Texas Rangers AL |
| 102. | Harmon Killebrew - 46 - 1961 - Minnesota Twins AL |
| 103. | Derrek Lee - 46 - 2005 - Chicago Cubs NL |
| 104. | Eddie Mathews - 46 - 1959 - Milwaukee Braves NL |
| 105. | Carlos Pena - 46 - 2007 - Tampa Bay Devil Rays AL |
| 106. | Albert Pujols - 46 - 2004 - St. Louis Cardinals NL |
| 107. | Jim Rice - 46 - 1978 - Boston Red Sox AL |
| 108. | Babe Ruth - 46 - 1924 - New York Yankees AL |
| 109. | Babe Ruth - 46 - 1931 - New York Yankees AL |
| 110. | Babe Ruth - 46 - 1929 - New York Yankees AL |
| 111. | Alfonso Soriano - 46 - 2006 - Washington Nationals NL |